This peptide, a known IgE binding sequence from Ara h 2, could somewhat inhibit degranulation by Ara h 2 from the LAD2 mast cell line. There were also difficulties with solubility of the peptides but work was done with the most soluble, peptide 1, as of this progress report. For instance, more than 50 of children with a peanut allergy test positive to other beans (pea, soy, string bean, etc.) but only about one in 20 experience. Originally, the grant had proposed use of human basophils, however, the variability between donors was too high to visualize the slight differences in basophil activation that could be expected by inhibition of only one IgE epitope using the synthesized peptides. 3 PFAS is possibly the most common food allergy in adults, with up to 60 percent of patients allergic to pollen be. The peptides described in Aim 2 are undergoing evaluation of their ability to inhibit degranulation of a mast cell line and basophil cell line. Pollen Food Allergy Syndrome (PFAS), also known as Oral Allergy Syndrome (OAS), is an allergic reaction that typically occurs after a patient who is sensitive to pollen eats certain foods, e.g., fruits, vegetables, nuts, and grains. It was clear that the walnut sensitive individuals recognized sequences selected from walnut allergens better than the patients who were sensitive only to peanuts, or cross-reactive with a mild allergy to walnut. Aim 3 : The data were observed in terms of the degree of cross reactivity of the patients for peanuts and tree nuts.
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